Abstract: Based on the calculation method of furnace zoning heat transfer, a boiler system for 300 MW coal-fired power station was designed by using a supercritical CO₂ (S-CO₂) Brayton cycle system with primary intercooling and secondary reheating & regenerating. The effects of the boiler zoning layout on the temperature distribution along the gas-cooled wall and furnace as well as the pressure drop of the working fluid were analyzed emphatically. Results show that under the design load, when the superheated gas-cooled wall is located at 0.71 of the chamber height, the flue gas temperature is within a reasonable range, and the furnace gas-cooled wall temperature has a wide safety margin,meanwhile the design cost is relatively low. Moreover, the cycle efficiency of the proposed circulation system can reach 51.82%, which is 1.79% and approximately 11% higher than that of a S-CO₂ primary reheating coal-fired boiler and a conventional steam boiler at the same class respectively.