Abstract: To solve the problems existing in large-capacity high-parameter units caused by increased height, lengthened pipeline and increased pressure loss of boiler, a new settlement boiler design was proposed, which makes the turbine platform and the boiler superheater-reheater platform on the same plane, so as to shorten the length of the main steam pipe and the cold/hot segment of reheated steam pipe. An analysis was performed on the variation of the pressure loss, the thermal economy and the cost of power generation resulted from the changes of pipe length. Results show that via the design of settlement boiler, the pipe length can be shortened significantly. When the main steam pipe, the cold segment and hot segment of reheated steam pipe are all shortened by 120 m, the thermal efficiency of the power unit will be increased by 0.18%, while the coal consumption be reduced by 1.044 g/(kW·h), and the initial investment of pipe material be reduced by 65 million RMB. Based on annual utilization hours of 5 249 h and coal price of 600 RMB/t, the annual coal consumption would be reduced by 6 093 t, meaning the fuel cost would be lowered by 3.66 million RMB/year, and the power generation cost would be reduced by 0.002 8 RMB/(kW·h).