Abstract: To make use of the advantage of organic Rankine cycle for low-temperature waste heat recovery, a waste heat power generation system driven by solid oxide fuel cell (SOFC) was proposed based on organic working medium, including an internal reforming SOFC, an after-burner, a gas turbine, compressors, pre-heaters and ORC, which can help to realize gradient utilization of energy, and improve total power generation efficiency of the system. Based on a steady-state mathematical model, an analysis platform was established for thermodynamic simulation of the system, so as to study the effects of key parameters on the system performance. Results show that the total power generation efficiency of the system may reach 65% under design conditions; with the rise of fuel flow, the net power output increases, however, the total power generation efficiency decreases; within a certain range, the increase of compressor pressure ratio is beneficial to improvement of both the net power output and total power generation efficiency; with the increase of steam/carbon molar ratio, both the net power output and the overall power generation efficiency decrease.