Abstract: Numerical simulations were conducted to study and analyze the wear law of SCR denitration catalysts in various areas at different flue gas flow rates and incident angles using CFD software, and subsequently the annual wear of the catalysts was predicted. Results show that the wear rate at the end face of catalyst is much higher than that of the wall. At different flue gas flow rates, the wear rate exhibits the same variation law along the direction of the channel, which is relatively small in the middle region and large in the vicinity of the cross section. At different incident angles, the wear rate of front surface is proportional to the incident angle within 0.04 m away from the inlet, and is inversely proportional to the incident angle beyond 0.04 m; the wear rate of back surface decreases rapidly near the inlet along the direction of the channel, which then increases gradually up to the outlet. At different incident angles, the wear rate of end face reduces with the rise of incident angle. When the denitration system operates under design conditions, the annual wear of the catalyst is negligible, but when the flue gas flow rate gets up to 11 m/s, the wall surface of the catalyst would be worn through within one year, therefore in actual operation process, the flue gas flow rate should be reduced and the incident angle should be reasonably determined.